Serum Ischemia-Modified Albumin Levels in Experimental Model of Acute Pancreatitis.

OBJECTIVE To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. STUDY DESIGN Randomized controlled trial. PLACE AND DURATION OF STUDY Experimental Animal Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, from May to September 2013. METHODOLOGY Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. RESULTS Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. CONCLUSION The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.